Most root canals are filled with gutta-percha points in combination with an endodontic sealer which are essential components of root canal obturation to establish a fluid-tight seal
The main objective of a root canal sealer is to provide a fluid tight seal. The purpose of this systematic meta-analysis was to determine the relative toxicity of commonly used root canal sealers like zinc oxide eugenol, calcium hydroxide, and resin-based sealers